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While this efficiency is generally beneficial, in environments of excess caloric intake it may contribute to fat accumulation

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However, it is important to note that results from animal experiments may not directly apply to humans

At excitatory synapses, GSK3 phosphorylates PSD95 and modulates excitatory synaptic plasticity in an N-Methyl-D-Aspartate (NMDA) receptor-dependent manner by inducing -Amino-3-hydroxy- 5-Methyl-4-isoxazolepropionic acid (AMPA) receptor internalization and thus LTD (Nelson et al., 2013) while ERKs boost excitatory synaptic and structural plasticity at different levels (Zhu et al., 2002