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Accordingly, male PAR2-G37I mice showed improved glucose tolerance in a GTT, whereas male PAR2-R38E mice showed a partial, insignificant reduction in glucose levels (Figure 3, D and F)

Subsequently, the team further found that intrathecal administration of SM has demonstrated potent, dose-dependent, and long-lasting anti-allodynic effects in neuropathic pain models induced by spinal nerve injury [72]

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Extracellular fluid volume expansion uncovers a natriuretic action of GLP-1: a functional GLP-1-renal axis in man