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In the aerobic pathway, PA is transformed to protocatechuate 35,36 through cis -4,5-dihydro-4,5-dihydroxyphthalate in Gram-negative bacterium or cis -3,4-dihydro-3,4-dihydroxyphthalate and 3,4-dihydroxyphthalate in Gram-positive bacterium 35

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In contrast to the lack of brain entry of dopamine in vivo [68], our results with the targeted dopamine-nanoformulation using the BBB model combined with midbrain organoids indicate that the nanoformulation may help dopamine to reach the brain tissue after BBB penetration

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