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Long-term HFD consumption increased hepatic IKK- glutathionylation and NF-B suppression The mechanistic investigations in our cell culture studies provided evidence suggesting that intracellular GSSG accumulation sensitizes hepatocytes to TNF cytotoxicity via the induction of IKK- glutathionylation, leading to reduced IKK- phosphorylation and subsequent NF-B suppression

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Then, 150 L of reducing reagent was added

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While unique, certain transcriptional subsets of eosinophils displayed partial overlap with previously described inflammatory eosinophils in the gastrointestinal tract