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In his case, the conflict took a toll on his mind when the end of the world appeared to be imminent

In this model, scheduled visits from weeks 4208 (that is, including the additional laboratory data collection visits for European patients) for the full analysis set were included as fixed effects, and interactions with treatment and baseline allowed the treatment effect and the importance of the baseline to vary over visits

Contacts that provided robust cortical control signals for closed-loop aDBS, which improved clinical efficacy while minimizing adverse effects, were more proximal to SCAN than to effector regions (Extended Data Fig

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