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In line with this context, the metabolites generated by the gut microflora can affect how well metformin works as a treatment contributing to interindividual variability in the drugs response

Despite these encouraging mechanistic and preclinical findings, the KD should be viewed strictly as an adjunctive, not curative, strategy

The Lancet, 370 , 20112019

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It can be challenging to produce certain nanoparticles on a large scale for therapeutic applications due to their initial complex, expensive, and unreliable preparation procedure