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Previous experience evaluating the salmon calcitonin RLD product, Miacalcin, indicated that a component of the formulation buffer was toxic to cells in culture or impacted the health of the cells such that response rates to Miacalcin, but not the salmon calcitonin API peptide, were lower than expected based on the known clinical immunogenicity data (24)
The first randomized, double-blind, placebo-controlled trial using liraglutide after MBS was performed by Lofton et al
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