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Another critical challenge involves the lack of standardized research methodologies, including inconsistency in dosing strategies, routes of administration, treatment durations, and outcome measures
Patients with T2DM, persons at risk for AD, had a significantly lower associated risk of AD after administered exenatide, liraglutide and dulaglutide ( Conclusion Increasing evidence suggests that anti-diabetes medicine, GLP-1R agonists, have multiple neuroprotective mechanisms in AD models, such as anti-inflammation, anti-oxidative stress, reducing A aggregation/deposition and tau protein hyperphosphorylation, reducing neuronal apoptosis and neurotoxicity, increasing cell proliferation and neurogenesis, increasing synaptic plasticity, and other beneficial effects
doi: 10.1038/s41421-021-00258-1 177 MagnaniH
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It also measures the greatest distance between two similar lesions in each anatomical region, such as axillae, buttocks, genitalia, and others, on both the left and right sides of the body (216)
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