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Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models

This hypothesis is supported by post-mortem evidence of reduced pyruvate dehydrogenase activity in the brains of individuals with ASD ( Alongside impairments in carbohydrate metabolism, evidence of reduced carnitine levels suggest a dysfunction in mitochondrial -oxidation, leading to accumulation of long-chain fatty acids and elevated markers of lipid elongation and desaturation (Pastural et al., 2009)

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Lithium aluminum hydride (7.50 g, 197.63 mmol) was added into a solution of 2,2-(propane-2,2-diylbis(sulfanediyl))diacetic acid (11.10 g, 49.55 mmol) in dry tetrahydrofuran (200 mL)