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Also, many environmental toxins such as lead and mercury, agricultural pesticides and herbicides, dioxin, and PCBs

- Vitamin C is an external antioxidant that, together with glutathione and vitamin E, forms a non-enzymatic antioxidant system in cells

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Second, as CG-rich genes are preferentially regulated at the transcriptional elongation stage, this might give them a selective advantage of becoming rapidly upregulated on appropriate stimuli (Hargreaves et al., 2009