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they were tested against lifestyle management interventions," he said

The discovery of the antidiabetic effects of exendin-4 increased the interest in this peptide, and several pharmaceutical companies thus focused on its clinical development as well as on discovery efforts in exendin-based GLP-1 analogs

For long-acting agents such as semaglutide, clinicians generally recommend stopping therapy at least two months before attempting pregnancy due to the extended half-life

Her improvement with a GLP-1 agonist was attributed to anti-inflammatory effects, such as the reduction of IL-17 and IL-6 levels

This strategy mirrors the approach used with GLP-1 maintenance dosing , where starting low and titrating up reduces side effects across the board