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The increase in cAMP levels in -cells is a consequence of GLP-1R activation in these cells, which in turn enhances the secretion of growth inhibitory hormone through signaling pathways such as PKA and Calcium/Calmodulin-dependent protein kinase (Strowski et al., 2000

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the closest-analog combination (cagrilintide + semaglutide in REDEFINE 1) shows clear additive benefit