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In the past ten years, a series of Phase III trials showed that the synthetic GLP-1/GIP agonists are effective in lowering blood sugar in type 2 diabetic subjects who were both treatment-nave or on typical first-line therapies such as metformin and insulin

Neurobiol Dis

This would be reminiscent of what is occurring in ALS patient spinal cord motor neurons with loss of cuproprotein function and thus overall function that precedes the eventual death of the neurons themselves (Hilton et al., 2024

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