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In patients with T2D in a phase 2 clinical trial, retatrutide (0.5 to 12 mg) significantly reduced body weight and HbA1c levels compared to placebo and 1.5 mg dulaglutide

The patients using both tend to be longevity-focused, productivity-oriented, and proactive about aging rather than reactive

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In a post hoc analysis of the SUMMIT trial, the decrease in estimated blood volume seen in participants treated with tirzepatide was significantly correlated with decreased blood pressure, lower microalbuminuria, improved KCCQ-CSS, and greater 6-min walking distance [85]