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The statistical analyses were conducted using GraphPad Prism 9.0 (GraphPad Software, CA, USA), and the ShapiroWilk test was employed to check for normal data distribution
Striatum D3R D3R expressed on striatal neurons can raise dopamine concentration, decrease -Syn accumulation, enhance secretion of BDNF, ameliorate neuroinflammation, alleviate oxidative stress, and promote neurogenesis in the nigrostriatal pathway
Many investigators benefit from examining a panel of related compounds in parallel, as this approach can reveal differential effects and structure-activity relationships not apparent from single-compound studies
Mouse lymphoma model and tumor xenografts The previously described mouse model of Burkitt lymphoma C57BL/6N-Tg(IGL-MYC)3Hm (-MYC mice) [35] was obtained from the NCI mouse repository (Strain code 01XA7), backcrossed to C57BL/6J for more than 10 generations, and maintained in heterozygosity in a C57BL/6 J background
The idea was further validated by inhibiting glutathione synthesis by BSO where Sp administration caused GSH to increase by ~1.5 fold with concomitant reduction in GSSG (Fig
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