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Objectively measured outcomes, such as degree of curvature or plaque characteristics or penile dimensions or ED, are critically important to establish that a therapy is effective in reducing these manifestations of PD

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This was emphasised in the CANTOS trial, in which a monoclonal antibody targeting IL-1 in individuals with established atherosclerotic CVD and evidence of systemic inflammation reduced the risk of major adverse cardiovascular events (MACE) by 1517%, an effect that was likely to be mediated by reductions in serum CRP concentrations [80, 81]