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doi: 10.1016/j.molmet.2020.101102 107 LongoMScappaticcioLCirilloPMaioACarotenutoRMaiorinoMIet al

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A useful comparison point is the acylation chemistry described for semaglutide by Lau and colleagues in the Journal of Medicinal Chemistry in 2015 [2], which introduced a C18 diacid linked through a spacer to achieve albumin binding on a GLP-1 scaffold

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