Ovarian cancer is the sixth most common malignancy among women in developed countries and the fifth leading cause of cancer-related death, representing a complex disease associated with poor survival rates.24 The combination chemotherapy of Paclitaxel (PTX) and Carboplatin (CARB) is considered the first-line treatment regimen for ovarian cancer.25 Both agents play distinct roles in inhibiting the growth of ovarian cancer through different mechanisms,26 and they are known to exert a synergistic anti-tumor effect by activating separate apoptotic signaling pathways, thereby potentially reducing drug resistance.25 The gonadotoxic effects of platinum-based chemotherapeutic agents have been demonstrated in numerous studies, both histopathologically and in terms of follicular development.27-29 In the present study, CARB administration led to significant histopathological damage in ovarian tissue, including follicular degeneration, prominent stromal edema, congestion, hemorrhage, inflammation, and fibrosis, particularly in the medullary region
Direct vaccination method It is suitable for small or small samples and can be directly inoculated into the culture medium for cultivation
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Evidence from an animal model suggest that taurine may protect kidney tissue from injury induced by alcohol metabolism (Latchoumycandane 2014)
Glutathione injections reduce melanin production by converting dark eumelanin to lighter pheomelanin while neutralizing free radicals that cause uneven pigmentation and skin damage
