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The clinical presentation can vary widely depending on the type of mutation affecting SLC22A5 and the phenotypic manifestation of the mutation, i.e., age of onset, organ involvement, and severity of symptoms at the time of diagnosis (34)

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On the other hand, estrogens phenolic hydroxyl group can act as an anti-oxidant agent, being a protective factor against cardiovascular and neurodegenerative diseases (Kumar et al., 2010)

Additionally, GCH1, a rate-limiting enzyme synthesized by BH4, has the potential to suppress ferroptosis [117]