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Under physiological conditions, GSH quenches oxidizing substances (such as reactive hydroxyl free radicals, peroxynitrite, and H 2 O 2 ) directly or reduces hydrogen peroxide (or lipid peroxide (lipid-OOH)) to water (or the corresponding lipid alcohol (lipid-OH)) under the catalysis of GPX (summarized in Fig

Given the harmful effects of eryptotic RBCs on endothelial cells and platelets, which can cause vascular inflammation and blood coagulation, these studies provide a rationale that links cigarette smoke to vaso-occlusive complications and atherogenesis

Genotype, enzyme activity, glutathione level, and clinical phenotype in patients with glutathione synthetase deficiency

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Further proof of the efficacy of glutathione IV infusion is the reduction of malondialdehyde, which is a marker of hepatic cell damage