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Additionally, injecting the drug into the amygdala of male mice also showed that the drug can be used to reduce nicotine withdrawal related anxiety

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In chronic cigarette smoke exposure-induced PH in rodents, the renin-angiotensin system has been shown to be activated and treatment with angiotensin-II (Ang-II) type I receptor antagonist losartan attenuates cigarette smoke-induced pulmonary vascular remodeling and PH

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