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There are resources to help smokers quit, including Smokefree.gov

Any tobacco user, whether present or past, who exhibits any of the following symptoms should seek immediate medical attention: Persistent breathlessness or cough that does not resolve with standard treatment Changes in voice or hoarseness that last longer than three weeks Difficulty swallowing or speaking Oral lesions, including red patches (erythroplakia), or white patches (leukoplakia), restricted mouth opening (trismus), or non-healing sores Chest tightness or pain may indicate lung involvement, cardiovascular damage, or both

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If the mutations inhibit programmed cell death, the cells can survive to become cancer cells