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When oxandrolone was administered at levels nine times greater than what a human would get, the consequences on female animal progeny included masculinization of the fetus, infertility, and teratogenic effects, including embryotoxicity and fetotoxicity

The selected dose of 120 mg/kg body weight is a well-established one for inducing significant and consistent testicular oxidative stress and spermatotoxicity in rodent models, as extensively documented in the literature 39