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We know that for every 10 percent increase in cigarette price, overall cigarette consumption is reduced by 3 to 5 percent

& Kleihues, P.) (IARC, Lyon, 2003)

Specific bacteria, viruses, and parasites can alter how cells function, weaken the immune system, or cause chronic inflammation, mechanisms that contribute to cancer development

I expect that meaning would have been taken by early colonists to the U.S., says Bengry, transported with anglophone people to North America. So, when it was first noted in reference to homosexuals much later, around the 1910s, It wouldnt have just grown out of nothing in the United States