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CHANGE-seq-BE sensitively identifies bona fide off-target sites in human primary cells To systematically assess the genome-wide off-target activity of ABEs and CBEs in vitro, we performed CHANGE-seq-BE on five therapeutically relevant target sites in human primary T cells ( B2M , CBLB , CD7 , CIITA and PDCD1 ) 25 and in human primary hepatocytes ( PCSK9 ) 26 with ABE8e (Fig

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It is more flexible than a hard box and can bend slightly when placed in a pocket, bag, or storage space

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