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2 Causes & Contributing Factors Food Allergies Food allergies can be categorized as follows 5 : IgE-mediated allergies, also called hypersensitivities, that result in significant release of inflammatory factors such as histamine, leukotrienes, and cytokines NonIgE-mediated food allergies where T cells of the immune system release inflammatory chemicals in response to signals other than those mediated by IgE Mixed-type food allergies, which have features of both IgE- and nonIgE-mediated allergies The primary differences between these types of allergies are the part of the immune system involved in reacting to an allergen and often the timing of the response