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In the context of various depression phenotypes, insulin resistance did not increase in the context of the MDD phenotypes

2,3 However, most transcription factors are notoriously undruggable due to an intrinsic disorder in their structure owing to convex DNA binding interface and flatter protein binding interface, rendering difficulties in targeting their functional associations with DNA or proteins

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Researchers continue to investigate its biochemical characteristics, receptor interactions, stability profile, and analytical properties in controlled laboratory environments