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New opportunities and old challenges in the clinical translation of nanotheranostics

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In an upcoming issue, Part 2 will conclude with methods of detection and strategies for validation of stability-indicating methods

Here we review receptor biology and coactivator coupling, the pharmacology of SLU-PP-332 in cells and animals, dosing paradigms and route considerations used in published studies, translational biomarkers and experimental endpoints, context-dependent risks and unknowns, and practical guidance for nonclinical study design