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Users become physically dependent on crack cocaine when they become tolerant to the drug, and start using higher amounts to achieve its effects

Therefore, we aim to test a secondary hypothesis that baseline nicotine metabolite ratio (NMR) will moderate the experimental treatment effect, such that the benefit of dose titration will be greater in those participants who are rapid metabolizers of nicotine, and the final titrated dose they reach will be higher on average than the slow metabolizers

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Menthol smoking prevalence now exceeds non-menthol smoking prevalence among both youth and young adults