this includes chlorambucil (adduct formation through nucleophilic substitution of the atom of chlorine [118]), cyclophosphamide (acrolein is one its main metabolites conjugating to GSH and becoming significantly less cytotoxic than the parent compound [119]), mitomycin C (forming mono- and bis-conjugates with GSH to be detoxified [120]), and various tyrosine kinases inhibitors (such as axitinib and sunitinib [121])
Their mass use for cosmetic weight loss is new territory, and we are navigating it in real time, with millions of people as the data
For women who are pregnant or planning pregnancy, tighter TSH targets and more frequent monitoring are required, and specialist advice should be sought
This decrease in enzyme activity can lead to a buildup of a substance called homocysteine in the blood, which is associated with an increased risk of cardiovascular disease, stroke, and other health problems
Data Collection Data were extracted from the included studies using a standardized data extraction form by 2 reviewers
