Popular Brands Hospira (Pfizer) Cyanocobalamin Injection American Regent Cyanocobalamin Fresenius Kabi Cyanocobalamin Sandoz Cyanocobalamin Teva Cyanocobalamin Strengths 1000 mcg/mL (standard adult & clinical dose) 500 mcg/mL (pediatric or dose-adjusted therapy) 2000 mcg/mL (high-strength for severe deficiency) Typical regimen: 1000 mcg IM weekly, then monthly maintenance (per healthcare providers direction)
Results are typically visible within a few weeks of starting, with more significant progress occurring over several months as the treatment continues
Mechanistically, NMD is dependent on the presence of at least one EJC, and targeting this pathway with ASOs led to the increase of MECP2 gene expression within in vitro mammalian cell models [105]
Side effects vary between patients and may include Nausea, vomiting, diarrhea, constipation, upset stomach, heart burn, tiredness, or dizziness