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Existing frameworks for high-risk drugs, such as the NICE guidelines for stimulant prescribing in ADHD and opioid safety protocols, could serve as models, emphasising structured assessment, multidisciplinary oversight, ongoing monitoring and follow-up

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A recent phase 3, double-blind clinical trial evaluating the efficacy of sarilumab in giant cell arteritis demonstrated that treatment with 200 mg sarilumab combined with a 26-week glucocorticoid tapering regimen achieved the primary endpoint of sustained remission, highlighting a novel therapeutic application of sarilumab in this domain [351]

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