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By February 2025 for semaglutide and March 2025 for tirzepatide, FDA declared both shortages resolved and transitional exemption windows ended

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The medication is administered once weekly via subcutaneous injection, with doses typically initiated at 2.5 mg (an initiation dose not intended for glycemic control) and gradually titrated upward (5 mg, 7.5 mg, 10 mg, 12.5 mg, to a maximum of 15 mg) based on glycemic response, weight loss goals, and tolerability

Loss of fat tissue Research has found that Ozempic tends to reduce fat mass more than muscle mass