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IBD is associated with the dysregulation of the symbiotic relationship between the commensal ecosystem and the mucosal immune system ( Crohns disease (CD) and ulcerative colitis (UC) are the two major phenotypes of IBD, and they differ meaningfully in their biology, barrier injury patterns, and epithelial restitution mechanisms

Gier et al (38) reported PanIN lesions located primarily in pancreatic duct glands of normal rats treated with exendin-4

CHD-C MMP-7: 47 ng/dL (IQR 38-94 ng/dL), p 4.0 mg/dL for disease groups vs 0.05 mg/dL for nCC

Avoiding rich, spicy, or heavily scented foods that may trigger nausea

The competitive question is therefore not oral vs injectable, but: which assets can win on both efficacy and frictionless adoption, without creating new safety or adherence tradeoffs