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This dual action distinguishes it from single-action GLP-1 agonists like semaglutide and may explain why some patients achieve stronger weight loss outcomes with tirzepatide

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The most commonly reported side effects for both include: Nausea, particularly during dose escalation Vomiting Diarrhea or constipation Reduced appetite (which is also the intended mechanism) Fatigue in some patients These side effects are most pronounced early in treatment and during dose increases

Originally developed to treat type 2 diabetes, doctors noticed that patients taking these drugs often lost significant amounts of weight