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Additionally, GLP-1 RAs might stimulate sirtuin proteins like SIRT1, which play a crucial role in maintaining telomere integrity and preventing cellular senescence

Signal Transduct Target Ther 9(1):234

Handling of combinations is inconsistent, e.g

The HK-2 cells stimulated with a high concentration of glucose for 72 h exhibited an increased expression of the autophagic markers, LC3-II and Beclin1

Only a modest decrease in SF3B1 phosphorylation was observed after 1 h of CDK9 and CDK7 inhibition, whereas longer treatments ( 2 h) led to a substantial reduction in P-SF3B1 levels for all inhibitors (Fig