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Furthermore, a retrospective analysis of a Chinese cohort of knee OA patients with type 2 diabetes, those patients who had been prescribed a GLP-1 agonist (including liraglutide, semaglutide or other), exhibited reduced cartilage volume loss after 2 years, compared to those patients who had not been prescribed a GLP-1 agonist [78]

In addition, it has also been observed a SGLT2-i induced ACE2/ANG(1-7) pathway activation that may play a role in cardioprotection by competing with ANG II and AT1R (52)