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The heatmaps present fold-changes for RNAs significant at pFDR 2 for 3R4F and pFDR 2 indicate a high degree of confidence in this prediction obtained from a robust set of genes selected at pFDR 2

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Diseases induced by cigarette smoking are predominantly linked to hazardous constituents and combustion products, such as the carcinogens benzo[ a ]pyrene, 1,3-butadiene, and formaldehyde 4