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PMID: 33082173, PMCID: PMC8005796, DOI: 10.1136/heartjnl-2020-317101

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Key Research Findings: Studies have shown enhanced insulin secretion and greater improvements in glycemic control compared to GLP-1 agonists alone (Min & Bain

The clinical logic becomes clear when the full receptor context is considered: retatrutide also activates GLP-1 and GIP receptors, which stimulate glucose-dependent insulin secretion and counterbalance the glucagon-mediated glucose effects