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Glutathione-S-transferases kick-starts this reaction and GSH finishes the job

Both diets were obtained from Research Diets (New Brunswick, NJ)

(Basel, Switzerland: MDPI) (2021)

Impact of high-dose folic acid supplementation in pregnancy on biomarkers of folate status and 1-carbon metabolism: An ancillary study of the Folic Acid Clinical Trial (FACT)

Rather than mixing the powder into a large glass of water and swallowing it immediately, the manufacturer and functional medicine practitioners recommend placing the powder directly in the mouth (or mixing it with a tiny sip of water) and holding it under the tongue or against the cheeks for 30 to 90 seconds before swallowing