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Yes, GLP-1 receptor agonists can be safely used in people with high blood pressure and may produce modest reductions in systolic blood pressure

Analysis of subgroup of patients with HF in the EXSCEL trial revelaed that use of once-weekly exenatide reduced the risk of all-cause mortality in patient without HF (HR 0.79 [95% CI, 0.680.92]), while in patients with baseline HF no effect was observed (HR, 1.05 [95% CI, 0.851.29) (67)

[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Kastin AJ, Akerstrom V, Pan W

Sources: Diab H, Fuquay T, Datta P, Bickel U, Thompson J, Krutsch K