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alz-journals.onlinelibrary.wiley.com Verma S et al

Findings in mice, rats, rabbits, and dogs are a reasonable multi-species foundation, but rodents and dogs can differ from humans in metabolism, immune recognition of a foreign peptide, and susceptibility to particular toxicities

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First, they look for evidence that a drug acts on the biological processes that drive aging, such as inflammation, metabolism or the bodys ability to repair and recycle damaged cells