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Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM, Eckardt K, Kaufman JM, Ryden M, Muller S, et al

Since iron is an essential cofactor in multi-fold cellular processes, iron-chelation can have off-target effects and potentially cause untoward effects

Key peptides in this therapy include GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), which help regulate appetite, blood sugar, and fat metabolism

Semaglutide follows a gradual 4-week titration: Start 0.25mg weekly (weeks 1-4), increase to 0.5mg (weeks 5-8), then 1mg (weeks 9-12), 1.7mg (weeks 13-16), and maintain 2.4mg weekly

The efficacy and safety of INVOKANA monotherapy were assessed in subjects with type 2 diabetes mellitus who were inadequately controlled with diet and exercise