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In the SURMOUNT-1 trial, participants taking tirzepatide at the 15 mg dose lost an average of 20.9% of their body weight over 72 weeks

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Common Symptoms of Electrolyte Imbalance on GLP-1s Many side effects attributed directly to GLP-1 medications are actually worsened by dehydration and mineral depletion: Fatigue and brain fog: Low sodium impairs cellular energy production Persistent headaches: Often linked to inadequate sodium and magnesium Muscle cramps and weakness: Typically from insufficient potassium and magnesium Worsening nausea: Dehydration intensifies digestive discomfort Dizziness upon standing: Low blood volume from inadequate sodium Constipation: Magnesium and proper hydration support healthy motility Heart palpitations: Electrolyte imbalances affect cardiac rhythm Addressing hydration proactively can significantly improve how you feel during GLP-1 therapy